Search Article 
 Advanced search 
About us - Editorial board - Browse articles - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 889 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   

Browse articles
J Clin Imaging Sci 2011,  1:5

Sonographic Spectrum of Tunica Albuginea Cyst

1 Department of Radiology, Hospital San Jose Tec de Monterrey, Monterrey, Mexico
2 Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA

Date of Submission22-Sep-2010
Date of Acceptance02-Oct-2010
Date of Web Publication03-Dec-2010

Correspondence Address:
Daniel M Alvarez
Hospital San Jose Tec de Monterrey, Ave Morones Prieto No. 3000 Pte. Col. Doctores, Monterrey, N.L. Mexico C.P. 64710, Mexico

Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2156-7514.73503

Rights and Permissions

Tunica albuginea (TA) cyst is the most common extratesticular benign mass, which is usually palpable. Ultrasound examination is the imaging modality of choice to characterize palpable testicular lesions. This pictorial essay presents the spectrum of sonographic features of TA cysts in order to assist radiologists in making the correct diagnosis and avoid unnecessary surgeries.

Keywords: Testicular cyst, tunica albuginea cyst, tunica albuginea, ultrasound

How to cite this article:
Alvarez DM, Bhatt S, Dogra VS. Sonographic Spectrum of Tunica Albuginea Cyst. J Clin Imaging Sci 2011;1:5

How to cite this URL:
Alvarez DM, Bhatt S, Dogra VS. Sonographic Spectrum of Tunica Albuginea Cyst. J Clin Imaging Sci [serial online] 2011 [cited 2019 Feb 16];1:5. Available from:

   Introduction Top

Tunica albuginea (TA) cyst is the most common extratesticular benign mass, which is usually palpable. The purpose of this article is to describe the various sonographic appearances of the TA cyst.

Ultrasonography is the modality of choice for characterization of testicular lesions. Extratesticular lesions are more common than intratesticular lesions. More than 95% of intratesticular lesions are malignant. [1] Most malignant tumors are palpable, whereas the majority of intratesticular cysts are not palpable except when they are at the periphery of the testis. [2] Tunica albuginea cysts, regardless of size, are usually palpable.

   Discussion Top

Tunica albuginea cysts arise from tunica albuginea (TA). The TA, a fibrous layer below the tunica vaginalis, closely covers the testicle. The posterior surface of the TA extends into the interior of the testis, forming an incomplete septum known as the mediastinum testis. [2] The TA can be seen as a bilayered echogenic structure around the testicle [Figure 1]. [3]
Figure 1: Normal testicle. Longitudinal gray-scale ultrasound image of the testis shows the Tunica albuginea as a bilayered echogenic band surrounding the testis (arrows).

Click here to view

Benign tumors involving the tunica albuginea include TA cyst, adenomatoid tumor, and fibrous tumor. The incidence of TA cysts is 0.35%. [4]

Tunica albuginea cysts are the most common extratesticular benign masses, and most of the times are discovered incidentally by the patient. Patients usually present with a firm pinhead-sized palpable mass and rarely present with pain and swelling. [2] In 1929, Frater [5] described TA cysts as a separate disease entity from intratesticular cysts.

The pathogenesis of TA cyst is not known, but they are believed to be mesothelial in origin. [6] Under microscopic analysis, they are lined by non-ciliated cuboidal cells and contain serous fluid and cellular debris. [7]

Tunica albuginea cysts are characteristically located at the upper anterior or lateral aspect of the testicle. They may be associated with a history of trauma, hemorrhage, or infection. [8] Tunica albuginea cysts range from 2 to 5 mm in diameter and are brought to medical attention when a patient presents with a palpable lump. [5] The mean age at presentation is 40 years and can even be seen in the 5 th and 6 th decades. [2]

Non-neoplastic cystic lesions represent a subset of testicular lesions of which the majority are benign. It is important for the practicing radiologist to recognize this benign subset to prevent unnecessary surgical exploration. [2] Patients with an extratesticular nodule in the upper anterior or lateral aspect of the TA can be easily treated with enucleation.

   Spectrum of Sonographic Features Top

Simple cyst

This is the classic appearance of a TA cyst. Ultrasound reveals a small (2-5 mm), sharply demarcated, unilocular or multilocular cyst without solid components, no disturbance of the adjacent parenchyma, and with posterior through transmission [Figure 2]. [9] They are usually very firm, even when small. [2]
Figure 2: Classic Tunica albuginea cyst in a 34-year-old man. (a) Longitudinal and (b) transverse gray-scale ultrasound images demonstrate a well-defined cystic lesion in the anterior and upper portion of the testis (arrow), a characteristic location for a Tunica albuginea cyst. The TA cyst demonstrates through transmission (small arrows). (*Reproduced with permission from Radiographics.[2])

Click here to view

These cysts meet all the three criteria of a simple cyst - an imperceptible wall, anechoic center, and through transmission. They are avascular on color flow Doppler examination [Figure 3].
Figure 3: Tunica albuginea cyst. Longitudinal color flow Doppler image of the testis demonstrates classic location of the TA cyst with imperceptible wall, anechoic center, through transmission, and absence of blood flow.

Click here to view

Mimicking intratesticular cyst

Tunica albuginea cysts when large in size can compress the testicular parenchyma and may appear to be intratesticular in location, making the differentiation from an intratesticular cyst difficult [Figure 4]. [2] When larger than 10 mm, these cysts typically produce an indentation on the testicular parenchyma [Figure 5].
Figure 4: Tunica albuginea cyst mimicking an intratesticular cyst. Tunica albuginea cyst in an asymptomatic 70-year-old man, who had a palpable left testicular mass. Longitudinal ultrasound image shows a well-defined cyst with an imperceptible wall, an anechoic center, and through transmission. A diagnosis of intratesticular cyst was advanced. Findings of tumor markers were negative, but because the mass was palpable, the urologist suspected a malignant tumor. The patient underwent radical orchiectomy, after which a Tunica albuginea cyst was confirmed. (*Reproduced with permission from Radiographics.[2])

Click here to view
Figure 5: Tunica albuginea cyst mimicking an intratesticular cyst 35-year-old man with a palpable lump in the right testicle. (a) Longitudinal ultrasound image shows a 2.4 × 1.3 cm multilocular cystic lesion in the anterior aspect of the testis (arrow) producing a classic indentation on the testicular parenchyma. This lesion corresponded to the patient's palpable lump. (b) Color flow Doppler examination revealed no vascularity within the cyst.

Click here to view

If the large TA cyst corresponds to the palpable lesion, this feature can help differentiating intratesticular cyst from the TA cyst. The intratesticular cysts are not usually palpable and most of the time they are incidentally discovered on ultrasound examination. [10]

Calcified TA cyst

Tunica albuginea cysts may calcify and produce a posterior acoustic shadow [Figure 6]. [7] The etiology of calcification is not known and may be related to prior hemorrhage. Color Doppler examination, demonstrating twinkle artifact, may help in the diagnosis of calcified TA cysts [Figure 7].
Figure 6: Calcified Tunica albuginea cyst. A 24-year-old man with a palpable mass in the right testicle. Longitudinal ultrasound image shows a well-circumscribed calcified lesion (large arrow) with acoustic shadowing (small arrows).

Click here to view
Figure 7: Calcified Tunica albuginea cyst. (a) Longitudinal image show a unilocular, well-circumscribed lesion in the upper region of the testis (large arrow) arising from TA with calcifications inside it (arrowhead) with acoustic shadow (small arrows). Calipers outline the complete TA cyst. (b) Color flow Doppler examination demonstrates twinkle artifact (curved arrow) suggesting presence of calcium.

Click here to view

Milk of calcium

Milk of calcium describes the precipitation of calcium in a cyst or other fluid-containing structure with stasis that may be associated with low-grade inflammation. [11] It consists of small crystals of carbonate-apatite, hydroxyapatite, or calcium carbonate. [12]

The sonographic appearance of a cyst containing milk of calcium is that of highly echogenic material which may demonstrate layering in the dependent portion of the cyst or may completely fill the cyst giving an appearance of an echogenic lesion, which may not have posterior acoustic shadowing [Figure 8]. [9]
Figure 8: Tunica albuginea cyst with milk of calcium. (a) Longitudinal ultrasound image of the right testicle shows a well-defined homogeneous echogenic smooth-walled lesion measuring 6 × 4 mm in the upper anterior pole of the testicle without any acoustic shadow; this lesion corresponded to the palpable lump (arrow). (b) Color Doppler examination reveals no vascularity within the lesion (arrow). Tumor markers were negative.

Click here to view

Complex cyst

Poster et al [13] reported a benign complex TA cyst where the echogenic material proved to be inflammatory debris on pathological examination after orchiectomy.

These complex cysts present as a well-defined echogenic mass, with no calcium or cystic portions. There is absence of internal color flow on the Doppler examination [Figure 9].
Figure 9: Complex Tunica albuginea cyst. A 36-year-old man with a right testicular palpable mass. Transverse ultrasound image shows a heterogeneous 10 × 5 mm lesion in the upper anterior aspect of the testis arising from the TA (arrow); this lesion corresponded to the palpable abnormality.

Click here to view

   Differential Diagnosis of Tunica Albuginea Cyst Top

Tunica vaginalis cyst

Most of the scrotal tunica cysts arise from the TA, but they may arise from layers of the tunica vaginalis as well. [14]

Cystic lesions that arise from the visceral layers of the tunica vaginalis may be small or large. They may be idiopathic or post-traumatic in origin. In general, a cyst of the tunica vaginalis is completely anechoic [Figure 10], except in the occasional post-traumatic setting where they may demonstrate presence of internal echoes or calcium. [15] The tunica vaginalis cysts may be more easily recognized in the presence of hydrocele.
Figure 10: Tunica vaginalis cyst. (a) Longitudinal and (b) transverse ultrasound images of the left testicle show a moderate hydrocele and two simple cysts arising from the Tunica vaginalis (large arrows). Location of these cysts is away from the Tunica albuginea (small arrows).

Click here to view

Scrotal calculi

Also called as scrotal pearls or scrotoliths, are freely mobile calcified bodies that lie between the layers of the tunica vaginalis. Their origin is unclear. [14] They are usually seen as a sequela to hematoma or inflammatory changes within the scrotum, or loose bodies from a twisted epididymal or testicular appendix. [16]

Sonographically, scrotal calculi are seen as small (<1cm) echogenic foci with posterior acoustic shadowing [Figure 11] and [Figure 12]. [8] The presence of hydrocele facilitates their recognition.
Figure 11: Scrotal pearl. Transverse gray-scale ultrasound image of the left testicle shows moderate hydrocele and an echogenic round calcification lying adjacent to Tunica vaginalis corresponding to a scrotal pearl (arrow).

Click here to view
Figure 12: Scrotal pearl. Longitudinal gray-scale ultrasound image of the right testicle demonstrates a large hydrocele, with a scrotal pearl (arrow) with posterior acoustic shadowing.

Click here to view

   Conclusion Top

The TA cyst can have variable sonographic appearances, ranging from a simple cyst to that of a complex appearance including calcification or debris. These cysts do not demonstrate blood flow on color Doppler examination and have a typical location in the testis. It is important to recognize the various appearances of TA cysts in order to avoid unnecessary surgery.

   References Top

1.Moghe PK, Brady AP. Ultrasound of testicular epidermoid cysts. Br J Radiol 1999;72:942-5.  Back to cited text no. 1
2.Dogra VS, Gottlieb RH, Rubens DJ, Liao L. Benign intratesticular cystic lesions: US features. Radiographics 2001;21:273-81.  Back to cited text no. 2
3.Dogra VS, Gottlieb RH, Oka M, Rubens DJ. Sonography of the scrotum. Radiology 2003;227:18-36.   Back to cited text no. 3
4.Gooding GA, Leonhart W, Stein R. Testicular cyst: US findings. Radiology 1987;163:537-8.  Back to cited text no. 4
5.Frater K. Cysts of the tunica albuginea (cysts of the testis). J Urol 1929;21:135-40.   Back to cited text no. 5
6.Tammela TL, Karttunen TJ, Mattila SI, Mδkδrδinen HP, Hellstrφm PA, Kontturi MJ. Cysts of the tunica albuginea--more common testicular masses than previously thought? Br J Urol 1991;68:280-4.  Back to cited text no. 6
7.Warner KE, Noyes DT, Ross JS. Cysts of the tunica albuginea testis: A report of 63 cases with a review of literature. J Urol 1984;132:131-2.  Back to cited text no. 7
8.Bhatt S, Rubens DJ, Dogra VS. Sonography of benign intrascrotal lesions. Ultrasound Q 2006;22:121-36.  Back to cited text no. 8
9.Rubenstein RA, Dogra VS, Seftel AD, Resnick MI. Benign intrascrotal lesions. J Urol 2004;171:1765-72.   Back to cited text no. 9
10.Hamm B, Fobbe F, Loy V. Testicular cysts: Differentiation with US and clinical findings. Radiology 1988;168:19-23.  Back to cited text no. 10
11.Patriquin H, Lafortune M, Filiatrault D. Urinary milk of calcium in children and adults: Use the gravity dependent sonography. Am J Roentgenol 1985;144:407-13.   Back to cited text no. 11
12.Garret RA, Holland JM. Milk of calcium in caliceal diverticulum. J Urol 1973;109:927-9.  Back to cited text no. 12
13.Poster RB, Spirt BA, Tamsen A, Surya BA. Complex tunica albuginea cyst simulating an intratesticular lesion. Urol Radiol 1991;13:129-32.  Back to cited text no. 13
14.Garriga V, Serrano A, Marin A, Medrano S, Roson N, Pruna X. US of the tunica vaginalis testis: Anatomic relationships and pathologic conditions. Radiographics 2009;29:2017-32.  Back to cited text no. 14
15.Black JA, Patel A. Sonography of the abnormal extratesticular space. Am J Roentgenol 1996;167:507-11.  Back to cited text no. 15
16.Artas H, Orhan I. Scrotal calculi. J Ultrasound Med 2007;26:1775-9.  Back to cited text no. 16

   Authors Top

Dr. Daniel M. Alvarez


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10], [Figure 11], [Figure 12]

This article has been cited by
1 Perspectives in Pediatric Pathology, Chapter 8. Persistence of Embryonal Remnants in the Testis and Epididymis
Manuel Nistal,Ricardo Paniagua,Pilar González-Peramato,Miguel Reyes-Múgica
Pediatric and Developmental Pathology. 2015; 18(5): 353
[Pubmed] | [DOI]
2 Ultrasonography of scrotal diseases
Choonpa Igaku. 2014;
[Pubmed] | [DOI]


Previous article   Next article
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Spectrum of Sono...
    Differential Dia...
    Article Figures

 Article Access Statistics
    PDF Downloaded1169    
    Comments [Add]    
    Cited by others 2    

Recommend this journal