Search Article 
  
 Advanced search 
  
 
About us - Editorial board - Browse articles - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 413 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   



 
Browse articles
ORIGINAL ARTICLE
J Clin Imaging Sci 2016,  6:44

Computed Tomography Angiography with a 192-slice Dual-source Computed Tomography System: Improvements in Image Quality and Radiation Dose


1 Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
2 Department of Radiology, Erasmus Medical Center, Rotterdam; Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands

Date of Submission25-Jul-2016
Date of Acceptance07-Sep-2016
Date of Web Publication21-Oct-2016

Correspondence Address:
Philip V M Linsen
Department of Radiology, Erasmus Medical Center, CA-207, s-Gravendijkwal 230, 3015 CE, Rotterdam
The Netherlands
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2156-7514.192840

Rights and Permissions
   Abstract 

Purpose: This study aims to compare image quality, radiation dose, and the influence of the heart rate on image quality of high-pitch spiral coronary computed tomography angiography (CCTA) using 128-slice (second generation) dual-source CT (DSCT) and a 192-slice DSCT (third generation) scanner. Materials and Methods: Two consecutive cohorts of fifty patients underwent CCTA by high-pitch spiral scan mode using 128 or 192-slice DSCT. The 192-slice DSCT system has a more powerful roentgen tube (2 × 120 kW) that allows CCTA acquisition at lower tube voltages, wider longitudinal coverage for faster table speed (732 m/s), and the use of iterative reconstruction. Objective image quality was measured as the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Subjective image quality was evaluated using a Likert scale. Results: While the effective dose was lower with 192-slice DSCT (1.2 ± 0.5 vs. 0.6 ± 0.3 mSv; P < 0.001), the SNR (18.9 ± 4.3 vs. 11.0 ± 2.9; P < 0.001) and CNR (23.5 ± 4.8 vs. 14.3 ± 4.1; P < 0.001) were superior to 128-slice DSCT. Although patients scanned with 192-slice DSCT had a faster heart rate (59 ± 7 vs. 56 ± 6; P = 0.045), subjective image quality was scored higher (4.2 ± 0.8 vs. 3.0 ± 0.7; P < 0.001) compared to 128-slice DSCT. Conclusions: High-pitch spiral CCTA by 192-slice DSCT provides better image quality, despite a higher average heart rate, at lower radiation doses compared to 128-slice DSCT.

Keywords: Computed tomography, coronary angiography, heart rate, image quality, radiation dose


How to cite this article:
Linsen PV, Coenen A, Lubbers MM, Dijkshoorn ML, Ouhlous M, Nieman K. Computed Tomography Angiography with a 192-slice Dual-source Computed Tomography System: Improvements in Image Quality and Radiation Dose. J Clin Imaging Sci 2016;6:44

How to cite this URL:
Linsen PV, Coenen A, Lubbers MM, Dijkshoorn ML, Ouhlous M, Nieman K. Computed Tomography Angiography with a 192-slice Dual-source Computed Tomography System: Improvements in Image Quality and Radiation Dose. J Clin Imaging Sci [serial online] 2016 [cited 2017 Apr 27];6:44. Available from: http://www.clinicalimagingscience.org/text.asp?2016/6/1/44/192840


   Introduction Top


Due to its high sensitivity and negative predictive value, coronary computed tomography angiography (CCTA) has emerged as a reliable noninvasive examination to rule out coronary artery disease (CAD).[1],[2] However, exposure to radiation has remained an issue of concern.[3],[4] Over the past decade, technical innovations have decreased the radiation dose associated with CCTA, while maintaining good diagnostic performance.[5],[6]

For the second-generation 128-slice dual-source CT (DSCT) systems, a prospectively electrocardiogram (ECG)-triggered high-pitch spiral scan mode was introduced by which the entire heart could be scanned within the time of a single heart cycle. While the detector collimation does not completely cover the heart for a stationary table position, the entire heart can still be scanned by accelerating the spiral pitch (table advancement) and extending the exposure window during the single-beat acquisition. Previous studies have demonstrated that diagnostic image quality can be achieved at much lower radiation doses, particularly in patients with low heart rate.[7],[8],[9]

The 192-slice (third generation) DSCT system offers several technical improvements such as faster gantry rotation speed (from 280 to 250 ms), increased longitudinal detector coverage from collimation coverage (from 38 mm for 128-slice DSCT to 58 mm for 192-slice DSCT), and a more powerful roentgen tube (2 × 100 kW for 128-slice DSCT vs. 2 × 120 kW for 192-slice DSCT) that allows CCTA acquisition at tube voltages down to 70 kV. These improvements may allow for improved image quality, even at higher heart rates, while reducing radiation dose, when performing high-pitch spiral CCTA by 192-slice DSCT. This has been shown in ex vivo studies by Morsbach et al.[10]

In this study, we investigated the differences in image quality, radiation dose, and the influence of the heart rate on image quality in high-pitch spiral CCTA performed by 128 and 192-slice DSCT.


   Materials and Methods Top


Study design

For both 128 and 192-slice DSCT, the first, consecutive fifty patients scanned using a high-pitch spiral mode with known or suspect CAD were identified from medical records. Exclusion criteria were age younger than 18 years old, previous coronary artery bypass graft, and the inability to follow instructions needed for the CCTA. In case of second-attempt scans because of nondiagnostic image quality, only the first scan was included.

The 128-slice DSCT scans were performed between 28 April 2009 and 2 September 2009. The 192-slice DSCT scans were acquired between 3 March 2014 and 17 December 2014. According to institutional standard protocols, a noncontrast calcium scan was performed before CCTA. The calcium score was evaluated using dedicated software (CA Scoring; Siemens Medical Solutions, Forchheim, Germany) and expressed as the Agatston score.[11] The Institutional Review Board approved the study. Given the retrospective nature of the study, no informed consent was required.

Computed tomography acquisition

All patients received sublingual nitroglycerin before the CCTA examination. Intravenous beta-blockers were administered in patients with higher heart rates. Data acquisition was prospectively ECG-triggered to start at 65% of the R-R interval and completed within one cardiac cycle. All contrast-enhanced CCTA data were reconstructed with a slice thickness of 0.75 mm and slice increment of 0.3 mm.

The 128-slice DSCT system (Somatom Definition Flash, Siemens Medical Solutions, Forchheim, Germany) had a collimation of 2 × 128 × 0.6 mm, using a flying focal spot technique and a gantry rotation time of 280 ms.[12] The high-pitch spiral acquisition was made with a fixed pitch of 3.4 corresponding to a table movement of 4.58 m/s. Tube voltage (100 or 120 kV) was selected manually, and automatic exposure control (AEC) was used for the tube current. Images were reconstructed using filtered back projection and a medium-smooth kernel (B26f).

The 192-slice DSCT system (Somatom Force, Siemens Medical Solutions, Forchheim, Germany) had a collimation of 2 × 192 × 0.6 mm, using a flying focal spot technique and a gantry rotation time of 250 ms. The high-pitch spiral acquisition was made with a fixed pitch of 3.2 corresponding to a table movement of 7.37 m/s. Tube voltage was selected semi-automatically by the automatic selection algorithm, and AEC was used for the tube current. With 192-slice DSCT, the CCTA acquisition was possible at tube voltage levels between 70 and 120 kV in steps of 10 kV. Slices were reconstructed using a medium sharp kernel (Bv40), using model-based iterative reconstruction strength level 3 (ADMIRE; Siemens Medical Solutions, Forchheim, Germany).

Contrast protocols

The 128-slice DSCT protocol applied a bolus-tracking protocol. CCTA acquisition began once a threshold of 74 HU was exceeded within the ascending aorta. Timing of the scan using the 192-slice DSCT system was determined using a test bolus, planning the acquisition 8 s after peak enhancement of the test bolus. Most patients (94) were examined using iopromide 370 mg/l (Ultravist 370; Bayer Healthcare, Berlin, Germany), whereas six patients were examined using iodixanol 320 mg/l (Visipaque 320; GE Healthcare, Milwaukee, USA). For simplicity, the latter six patients (all in the 192-slice DSCT group) were not included in the contrast delivery comparison. The contrast injection was followed by a 45 ml saline chaser.

Objective image quality measurements

Both objective and subjective image quality was assessed using a dedicated workstation (Syngo.via, Siemens Medical Solutions, Forchheim, Germany). The objective image quality was assessed using the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Segments 1, 2, 3, 5, 6, 7, 8, 11, 13, and 15 were analyzed, in accordance with the coronary artery model of the Society of Cardiovascular Computed Tomography.[13]

Circular regions of interest (ROI), as large as possible, were placed in each coronary segment by one observer. The vessel wall, calcifications, plaques, or stents were carefully avoided. Coronary segments without interpretable lumen due to excessive plaque were excluded from the analysis. For the mean pericardial fat values, two samples near the right and left coronary artery were averaged. To calculate the SNR and CNR, the following formulas were used:[14]





The standard deviation (SD) of each ROI represented the image noise.[15] The CNR was calculated for the proximal segments 1, 5, 6, and 11, following the methodology by Achenbach et al.[16]

Subjective image quality

The subjective image quality was assessed independently by two observers blinded to the type of scanner and any other technical or medical information. A five-point Likert scale was used to score the image quality. The following scores were possible: 1 - poor, impaired image quality limited by excessive noise or poor vessel wall definition; 2 - adequate, reduced image quality either poor vessel wall definition or excessive image noise, limitation in low contrast resolution remain evident; 3 - good, effect of image noise, limitations of low contrast resolution, and vessel margin definition are minimal; 4 - very good, good attenuation of vessel lumen and delineation of vessel walls, relative image noise is minimal, coronary wall definition and low contrast resolution well maintained; 5 - excellent, excellent attenuation of the vessel lumen and clear delineation of vessel walls, limited perceived image noise.[17] For the final analysis of image quality in relation to acquisition properties, a consensus reading was performed for all segments with discordant scores beyond one point.

Radiation dose

The radiation dose was reported as volume CT dose index (CTDIvol), dose-length product (DLP), and effective dose (ED). For each patient, the CTDIvol was recorded from the automatically generated patient protocol. The estimated ED was calculated with the formula DLP × 0.014, using the 0.014 conversion factor for chest radiation (in mSv/Gy/cm) according to the European Guidelines for Multislice Computed Tomography and as adopted in large trials.[18],[19]

Statistical analyses

Continuous variables were expressed as mean ± SD or median (range) as appropriate, and categorical variables as frequencies or percentages. Student's t-test or Mann-Whitney U-test was used to compare the patient's characteristics, the amount and infusion rate of contrast, SNR, CNR, and radiation dose. Risk factors were analyzed using Chi-square test. To compare the subjective image quality, Mann-Whitney U-test was used. The impact of mean heart rate on image quality was assessed by Spearman's rank correlation coefficient. A two-tailed P < 0.05 was considered significant. The statistical analyses were performed with SPSS (version 21.0, SPSS Inc., Chicago, IL, USA).


   Results Top


Study population

The mean age in the 192-slice DSCT group was 57.1 ± 9.7 compared to 59.9 ± 10.9 in 128-slice DSCT group (P = 0.175). The mean heart rate during acquisition was higher for 192-slice DSCT (59 ± 7) compared with 128-slice DSCT (56 ± 6; P = 0.045) [Table 1]. In the 192-slice DSCT group, eight patients were rescanned due to movement/breathing artifacts (7) or an improperly set scanning coverage (1). Eleven patients were rescanned in the 128-slice DSCT group due to movement/breathing artifacts (9) or inadequate contrast timing (2) (P = 0.447). The second attempt scans were excluded from analysis.
Table 1: Baseline patient characteristics


Click here to view


Objective image quality

Mean coronary lumen attenuation was 572 HU for 192-slice DSCT and 401 HU for 128-slice DSCT. Mean subcutaneous fat attenuation was 123 HU for 192-slice DSCT and 107 HU for 128-slice DSCT. As seen in [Table 2], the mean SNR for scans made by 192-slice was higher (18.9 ± 4.3) than that for scans made by 128-slice DSCT (11.0 ± 2.9; P < 0.001). [Table 3] shows that the mean CNR was higher for 192-slice DSCT (23.5 ± 4.8) compared to 128-slice DSCT (14.3 ± 4.1; P < 0.001).
Table 2: Mean signal-to-noise ratio ratios


Click here to view
Table 3: Mean contrast-to-noise ratio ratios


Click here to view


Subjective image quality

Out of 500 potentially available coronary segments, 463 were evaluable for the 192-slice DSCT group and 454 in the 128-slice DSCT group (P = 0.302). The mean subjective image quality score for the 192-slice DSCT group was 4.2 ± 0.8 compared to 3.0 ± 0.7 in the 128-slice DSCT group (P < 0.001). Individual coronary segment scores were better on scans performed by 192-slice DSCT compared to 128-slice DSCT [Table 4].
Table 4: Mean image quality score per segment following the Likert scale


Click here to view


Impact of heart rate on image quality

There was a borderline significant correlation between low heart rate and mean image quality score on a per-patient analysis 128-slice DSCT (r = −0.278; P = 0.051) and less evident for 192-slice DSCT (r = −0.164; P = 0.265) [Figure 1].
Figure 1: The Influence of heart rate on image quality. It shows the linear regression plot of mean image quality scores overall coronary segments per patient (y-axis) against heart rate during computed tomography scanning (x-axis) in 128-slice dual-source computed tomography and 192-slice dual-source computed tomography. The dots represent the individual patients. The lines represent the Spearman's rank correlation coefficient. The lines show that image quality will decrease with higher heart rate. It also shows that 192-slice dual-source computed tomography is superior to 128-slice dual-source computed tomography in coronary computed tomography angiography at all heart rates and maintains good diagnostic image quality at higher heart rates.

Click here to view


Contrast

By including only patients scanned using iopromide 370 mg/l, the mean amount of contrast was lower for 192-slice DSCT (64.3 ± 4.1 ml compared to 75.6 ± 6.1; P < 0.001). The average infusion speed was 5.4 ± 0.2 ml/s for 192-slice DSCT and 5.9 ± 0.3 for 128-slice DSCT (P < 0.001).

Radiation dose

The radiation dose using 192-slice DSCT was lower than that at 128-slice DSCT (0.6 ± 0.3 mSv vs. 1.2 ± 0.5 mSv; P < 0.001). The tube voltage used was lower for the 192-slice DSCT, as 17 scans were made at 70 kV. The scan length was not significantly different [Table 5].
Table 5: Radiation dose


Click here to view



   Discussion Top


The main findings of this paper are that high-pitch spiral CCTA by 192-slice DSCT combined with iterative reconstruction is associated with better image quality and lower exposure to radiation and contrast medium, compared with 128-slice DSCT.

CCTA has developed as a reliable noninvasive diagnostic tool to assess CAD. In the recent years, there have been numerous technological improvements in CT technology to reduce radiation exposure while maintaining high image quality. As confirmed in our study, the 192-slice DSCT system allows for a further reduction in radiation dose.[8],[10],[20] With the latest 192-slice DSCT system, it is possible to perform CCTA with a radiation exposure far below 1 mSv in most of the patients. An example of good diagnostic quality imaging at 192-slice DSCT can be found in [Figure 2].
Figure 2: A 67-year old female with symptoms related to angina and an Agatston score of 632, a BMI of 24.3 kg/m2, and a heart rate during scanning of 67 beats per minute. (a) An example of a volume rendered multiplanar reconstruction of the right coronary artery (RCA) from a coronary computed tomography angiography performed at 192-slice dual-source computed tomography using a tube voltage of only 70 kV. (b) The same RCA in curved multiplanar reconstruction. Both demonstrate superior diagnostic image quality despite the low kV settings.

Click here to view


As seen in our study, radiation exposure was lowered by approximately 50% comparing 192- and 128-slice DSCT. This was partly because with 192-slice DSCT, a more powerful roentgen tube became available. This allowed CCTA at 70 kV rather than 100 kV at 128-slice DSCT.

The improvement in image quality with the 192-slice DSCT system is multifactorial. Faster rotation speed and wider coverage lower the sensitivity for motion artifacts. At lower tube voltage, the photoelectronic effect of iodine results in a higher signal and improved contrast with surrounding tissues. While on the other hand, the higher tube current avoids image noise, also iterative reconstruction algorithms contributed to improved SNR and CNR with 192-slice DSCT. In our study, we used a mean of 64 ml iodine contrast while contrast medium volumes in similar studies ranged from 10 to around 60 ml using 80 kV as the lowest tube voltage.[21],[22]

Similar to the findings by Ghadri et al., we did not observe a significant correlation between heart rate and image quality while using the high-pitch spiral scan mode, particularly for the 192-slice DSCT system.[23] There seems to be a negative tendency but, like the study by Ghadri et al., most likely this study is insufficiently powered to show a significant correlation.

Our results have to be evaluated in light of some limitations. The study is based on a historical comparison, and there is no guarantee that the populations are entirely comparable. In addition, experience with the performance of high-pitch spiral CCTA has increased over time. Improvement of image quality may be multifactorial, and not just the result of improved scanner hardware. Because the difference in attenuation between iodine and other tissues increases at lower kV tube setting, the attenuation values in the coronary lumen were higher for 192-slice DSCT despite the lower amounts of administrated contrast medium. The more robust capabilities for high-quality low tube voltage scanning in a less strictly selected population may bode well for the routine implementation of high-pitch spiral CCTA.

Furthermore, iterative reconstruction techniques were not yet available when 128-slice DSCT was introduced at our center. The use of iterative reconstruction for the 192-slice DSCT system further improved the SNR and CNR using algorithms which permit a decoupling of spatial resolution and noise.[24],[25],[26]


   Conclusions Top


High-pitch spiral CCTA on the 192-slice DSCT system results in higher image quality while the radiation dose is further reduced compared to 128-slice DSCT. The 192-slice DSCT system also allows for the use of the high-pitch spiral scan mode in patients with higher heart rates while maintaining good diagnostic image quality.

Financial support and sponsorship

Nil.

Conflicts of interest

Marcel L. Dijkshoorn: Consultant Siemens Medical Solutions. Koen Nieman: Institutional Research support from Bayer Healthcare, GE Healthcare, Siemens Medical Solutions.

 
   References Top

1.
Meijboom WB, Meijs MF, Schuijf JD, Cramer MJ, Mollet NR, van Mieghem CA, et al. Diagnostic accuracy of 64-slice computed tomography coronary angiography: A prospective, multicenter, multivendor study. J Am Coll Cardiol 2008;52:2135-44.  Back to cited text no. 1
[PUBMED]    
2.
Hong YJ, Kim SJ, Lee SM, Min PK, Yoon YW, Lee BK, et al. Low-dose coronary computed tomography angiography using prospective ECG-triggering compared to invasive coronary angiography. Int J Cardiovasc Imaging 2011;27:425-31.  Back to cited text no. 2
[PUBMED]    
3.
Einstein AJ, Henzlova MJ, Rajagopalan S. Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA 2007;298:317-23.  Back to cited text no. 3
[PUBMED]    
4.
Alkadhi H, Leschka S. Radiation dose of cardiac computed tomography - What has been achieved and what needs to be done. Eur Radiol 2011;21:505-9.  Back to cited text no. 4
[PUBMED]    
5.
Khan AN, Khosa F, Shuaib W, Nasir K, Blankstein R, Clouse M. Effect of Tube voltage (100 vs 120 kVp) on radiation dose and image quality using prospective gating 320 row multi-detector computed tomography angiography. J Clin Imaging Sci 2013;3:62.  Back to cited text no. 5
[PUBMED]  Medknow Journal  
6.
LaBounty TM, Leipsic J, Poulter R, Wood D, Johnson M, Srichai MB, et al. Coronary CT angiography of patients with a normal body mass index using 80 kVp versus 100 kVp: A prospective, multicenter, multivendor randomized trial. AJR Am J Roentgenol 2011;197:W860-7.  Back to cited text no. 6
[PUBMED]    
7.
Bischoff B, Meinel FG, Del Prete A, Reiser MF, Becker HC. High-pitch coronary CT angiography in dual-source CT during free breathing vs. breath holding in patients with low heart rates. Eur J Radiol 2013;82:2217-21.  Back to cited text no. 7
[PUBMED]    
8.
Meyer M, Haubenreisser H, Schoepf UJ, Vliegenthart R, Leidecker C, Allmendinger T, et al. Closing in on the K edge: Coronary CT angiography at 100, 80, and 70 kV-initial comparison of a second- versus a third-generation dual-source CT system. Radiology 2014;273:373-82.  Back to cited text no. 8
[PUBMED]    
9.
Deseive S, Pugliese F, Meave A, Alexanderson E, Martinoff S, Hadamitzky M, et al. Image quality and radiation dose of a prospectively electrocardiography-triggered high-pitch data acquisition strategy for coronary CT angiography: The multicenter, randomized PROTECTION IV study. J Cardiovasc Comput Tomogr 2015;9:278-85.  Back to cited text no. 9
[PUBMED]    
10.
Morsbach F, Gordic S, Desbiolles L, Husarik D, Frauenfelder T, Schmidt B, et al. Performance of turbo high-pitch dual-source CT for coronary CT angiography: First ex vivo and patient experience. Eur Radiol 2014;24:1889-95.  Back to cited text no. 10
[PUBMED]    
11.
Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr., Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990;15:827-32.  Back to cited text no. 11
    
12.
Flohr TG, Stierstorfer K, Ulzheimer S, Bruder H, Primak AN, McCollough CH. Image reconstruction and image quality evaluation for a 64-slice CT scanner with z-flying focal spot. Med Phys 2005;32:2536-47.  Back to cited text no. 12
[PUBMED]    
13.
Leipsic J, Abbara S, Achenbach S, Cury R, Earls JP, Mancini GJ, et al. SCCT guidelines for the interpretation and reporting of coronary CT angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee. J Cardiovasc Comput Tomogr 2014;8:342-58.  Back to cited text no. 13
[PUBMED]    
14.
Cademartiri F, La Grutta L, Runza G, Palumbo A, Maffei E, Mollet NR, et al. Influence of convolution filtering on coronary plaque attenuation values: Observations in an ex vivo model of multislice computed tomography coronary angiography. Eur Radiol 2007;17:1842-9.  Back to cited text no. 14
[PUBMED]    
15.
Ripsweden J, Brismar TB, Holm J, Melinder A, Mir-Akbari H, Nilsson T, et al. Impact on image quality and radiation exposure in coronary CT angiography: 100 kVp versus 120 kVp. Acta Radiol 2010;51:903-9.  Back to cited text no. 15
[PUBMED]    
16.
Achenbach S, Giesler T, Ropers D, Ulzheimer S, Anders K, Wenkel E, et al. Comparison of image quality in contrast-enhanced coronary-artery visualization by electron beam tomography and retrospectively electrocardiogram-gated multislice spiral computed tomography. Invest Radiol 2003;38:119-28.  Back to cited text no. 16
[PUBMED]    
17.
Leipsic J, Labounty TM, Heilbron B, Min JK, Mancini GB, Lin FY, et al. Adaptive statistical iterative reconstruction: Assessment of image noise and image quality in coronary CT angiography. AJR Am J Roentgenol 2010;195:649-54.  Back to cited text no. 17
[PUBMED]    
18.
The 2007 recommendations of the international commission on radiological protection. ICRP publication 103. Ann ICRP 2007;37:1-332.  Back to cited text no. 18
    
19.
Hausleiter J, Meyer T, Hermann F, Hadamitzky M, Krebs M, Gerber TC, et al. Estimated radiation dose associated with cardiac CT angiography. JAMA 2009;301:500-7.  Back to cited text no. 19
[PUBMED]    
20.
Hell MM, Bittner D, Schuhbaeck A, Muschiol G, Brand M, Lell M, et al. Prospectively ECG-triggered high-pitch coronary angiography with third-generation dual-source CT at 70 kVp tube voltage: Feasibility, image quality, radiation dose, and effect of iterative reconstruction. J Cardiovasc Comput Tomogr 2014;8:418-25.  Back to cited text no. 20
[PUBMED]    
21.
Schuhbaeck A, Achenbach S, Layritz C, Eisentopf J, Hecker F, Pflederer T, et al. Image quality of ultra-low radiation exposure coronary CT angiography with an effective dose <0.1 mSv using high-pitch spiral acquisition and raw data-based iterative reconstruction. Eur Radiol 2013;23:597-606.  Back to cited text no. 21
[PUBMED]    
22.
Komatsu S, Kamata T, Imai A, Ohara T, Takewa M, Ohe R, et al. Coronary computed tomography angiography using ultra-low-dose contrast media: Radiation dose and image quality. Int J Cardiovasc Imaging 2013;29:1335-40.  Back to cited text no. 22
[PUBMED]    
23.
Ghadri JR, Küest SM, Goetti R, Fiechter M, Pazhenkottil AP, Nkoulou RN, et al. Image quality and radiation dose comparison of prospectively triggered low-dose CCTA: 128-slice dual-source high-pitch spiral versus 64-slice single-source sequential acquisition. Int J Cardiovasc Imaging 2012;28:1217-25.  Back to cited text no. 23
    
24.
Gordic S, Desbiolles L, Sedlmair M, Manka R, Plass A, Schmidt B, et al. Optimizing radiation dose by using advanced modelled iterative reconstruction in high-pitch coronary CT angiography. Eur Radiol 2016;26:459-68.  Back to cited text no. 24
    
25.
Yin WH, Lu B, Hou ZH, Li N, Han L, Wu YJ, et al. Detection of coronary artery stenosis with sub-milliSievert radiation dose by prospectively ECG-triggered high-pitch spiral CT angiography and iterative reconstruction. Eur Radiol 2013;23:2927-33.  Back to cited text no. 25
[PUBMED]    
26.
Pontana F, Pagniez J, Flohr T, Faivre JB, Duhamel A, Remy J, et al. Chest computed tomography using iterative reconstruction vs filtered back projection (Part 1): Evaluation of image noise reduction in 32 patients. Eur Radiol 2011;21:627-35.  Back to cited text no. 26
[PUBMED]    

 
   Authors Top

Philip V M Linsen



    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]


This article has been cited by
1 Optimization of Dose and Image Quality in Adult and Pediatric Computed Tomography Scans
Kwo-Ping Chang,Tzu-Kun Hsu,Wei-Ting Lin,Wen-Lin Hsu
Radiation Physics and Chemistry. 2017;
[Pubmed] | [DOI]



 

Top
Previous article   Next article
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
    Materials and Me...
   Results
   Discussion
   Conclusions
    References
    Authors
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed1412    
    Printed6    
    Emailed0    
    PDF Downloaded83    
    Comments [Add]    
    Cited by others 1    

Recommend this journal