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Year : 2019  |  Volume : 9  |  Issue : 1  |  Page : 1

Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study

1 Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia
3 Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
4 Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia

Correspondence Address:
Dr. Shahid Bashir
Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcis.JCIS_61_18

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Objective: Investigation of brain structure in disease has been enhanced by developments in shape analysis methods that can identify subtle regional surface distortions. High-resolution magnetic resonance (MR) imaging was used to compare volumetric and shape analysis in schizophrenia (SCZ) patients and healthy controls (CON). Methods: T1-weighted, 1-mm thick MR images were acquired for 15 patients with SCZ and 15 age-matched healthy controls using subcortical volume and shape analysis, which we believe to be complimentary to volumetric measures. Results: SCZ patients showed significant shape differences compared to healthy controls in the right hippocampus (P < 0.005), left and right putamen (P < 0.044 and P < 0.031), left caudate (P < 0.029), right pallidum (P < 0.019), and left thalamus (P < 0.033). Conclusion: Our results provide evidence for subcortical neuroanatomical changes in patients with SCZ. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals of SCZ.

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