Journal of Clinical Imaging Science

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 9  |  Issue : 1  |  Page : 1-

Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study


Abdullah Abu Jamea1, Muhammed Alblowi2, Jamaan Alghamdi3, Fahad D Alosaimi2, Fahad Al-Bader1, Shahid Bashir4 
1 Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia
3 Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
4 Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia

Correspondence Address:
Dr. Shahid Bashir
Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam
Saudi Arabia

Objective: Investigation of brain structure in disease has been enhanced by developments in shape analysis methods that can identify subtle regional surface distortions. High-resolution magnetic resonance (MR) imaging was used to compare volumetric and shape analysis in schizophrenia (SCZ) patients and healthy controls (CON). Methods: T1-weighted, 1-mm thick MR images were acquired for 15 patients with SCZ and 15 age-matched healthy controls using subcortical volume and shape analysis, which we believe to be complimentary to volumetric measures. Results: SCZ patients showed significant shape differences compared to healthy controls in the right hippocampus (P < 0.005), left and right putamen (P < 0.044 and P < 0.031), left caudate (P < 0.029), right pallidum (P < 0.019), and left thalamus (P < 0.033). Conclusion: Our results provide evidence for subcortical neuroanatomical changes in patients with SCZ. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals of SCZ.


How to cite this article:
Jamea AA, Alblowi M, Alghamdi J, Alosaimi FD, Al-Bader F, Bashir S. Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study.J Clin Imaging Sci 2019;9:1-1


How to cite this URL:
Jamea AA, Alblowi M, Alghamdi J, Alosaimi FD, Al-Bader F, Bashir S. Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study. J Clin Imaging Sci [serial online] 2019 [cited 2019 Feb 23 ];9:1-1
Available from: http://www.clinicalimagingscience.org/article.asp?issn=2156-7514;year=2019;volume=9;issue=1;spage=1;epage=1;aulast=Jamea;type=0