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Pictorial essay


Angiogenesis imaging in neoplasia

David J BowdenTristan Barrett
Department of Radiology, Addenbrooke’s Hospital and University of Cambridge, Cambridge, UK
Date of Submission: 02-May-2011, Date of Acceptance: 21-Jun-2011, Date of Web Publication: 27-Jul-2011.
Corresponding Author:

David J. Bowden

Department of Radiology, Box 219, Addenbrooke’s Hospital and University of Cambridge, Cambridge, CB2 0QQ, UK.
E-mail: davidjbowden@googlemail.com

Corresponding Author:

David J. Bowden

Department of Radiology, Box 219, Addenbrooke’s Hospital and University of Cambridge, Cambridge, CB2 0QQ, UK.
E-mail: davidjbowden@googlemail.com

DOI: 10.4103/2156-7514.83229 Facebook Twitter Google Linkedin

ABSTRACT


Angiogenesis plays a key role in physiological and pathophysiological processes and is recognized as being essential for tumor growth and metastases. The recent oncological development of anti-angiogenic drugs brings with it a need for angiogenesis quantification and monitoring of response. The nature of these agents means that traditional anatomical methods of assessing morphologic change are outmoded and functional imaging techniques and/or agents are necessary. Herein, we describe the various imaging techniques that can be employed to assess angiogenesis, along with their inherent advantages and disadvantages and discuss the current and future developments in the field.
Keywords: Angiogenesis, Dynamic Contrast-enhanced Magnetic Resonance Imaging, Molecular Imaging, Positron Emission Tomography

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