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Case report


Penile Metastases of Recurrent Prostatic Adenocarcinoma without PSA Level Increase: A Case Report

Antonio PierroSavino CillaCinzia DigesùAlessio G Morganti
Date of Submission: 31-Mar-2012, Date of Acceptance: 12-Jun-2012, Date of Web Publication: 28-Jul-2012.
Corresponding Author:
Corresponding Author

Antonio Pierro

Radiology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Largo A. Gemelli, 1-86100 Campobasso, Italy.
E-mail: apierrojonico@libero.it

Corresponding Author:
Corresponding Author

Antonio Pierro

Radiology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Largo A. Gemelli, 1-86100 Campobasso, Italy.
E-mail: apierrojonico@libero.it

DOI: 10.4103/2156-7514.99178 Facebook Twitter Google Linkedin

ABSTRACT


We report a case of penile metastases from recurrent prostatic adenocarcinoma that was the first sign of a widespread metastatic disease in the absence of any increase in prostate-specific antigen (PSA) level. In April 2011, an 80-year-old man presented to our Radiotherapy Unit with multiple palpable hard nodules in the penis, dysuria, and moderate perineal pain, 7 years after he had received radiotherapy for prostate cancer. Nodules in the penis had appeared in February 2011. The ultrasound and magnetic resonance (MR) imaging suggested the diagnosis of multiple penile metastases. A total body computed tomography scan revealed a systemic spread of the disease, with multiple metastases in the liver, bones, and lungs. PSA level was 0.126 ng/ml. A fine needle aspiration biopsy of the liver lesion was undertaken, and the histopathologic examination revealed the prostatic origin of the metastases, so androgen deprivation therapy was started. The diagnosis of metastases should be considered in a patient with prior history of prostate malignancies presenting with solid nodules in the penis, even if the PSA level is low.
Keywords: Malignant Priapism, Penile Metastasis, Penile Nodules, Perineal Pain, Prostate Cancer

Cited in 5 Documents

  1. Elena G. Spinapolice, Chiara Fuccio, Barbara Rubino, Raffaella Palumbo, Mario Mensi, Laura Scopesi, Giuseppe Trifirò and Giovanni Battista Ivaldi (2014) Penile Metastases From Bladder and Prostate Cancer Detected by PET/CT: A Report of 3 Cases and a Review of Literature. Clinical Genitourinary Cancer 12(4):e155. doi: 10.1016/j.clgc.2014.03.013
  2. Zhengbang Dong, Chao Qin, Qijie Zhang, Lei Zhang, Haijing Yang, Jingdong Zhang and Fei Wang (2015) Penile metastasis of sigmoid colon carcinoma: a rare case report. BMC Urol 15(1):. doi: 10.1186/s12894-015-0014-9
  3. Valeria Fiaschetti, Valeria Liberto, Giulia Claroni, Giorgio Loreni, Vincenzo Formica, Mario Roselli, Alessandro Mauriello and Roberto Floris (2016) Relevance of computed tomography and magnetic resonance imaging for penile metastasis after prostatectomy: uncommon case report and brief review of the literature. Radiology Case Reports 11(3):255. doi: 10.1016/j.radcr.2016.04.003
  4. Ke Zhang, Jun Da, Hai-jun Yao, Da-chao Zheng, Zhi-kang Cai, Yue-qing Jiang, Ming-xi Xu and Zhong Wang (2015) Metastatic Tumors of the Penis. Medicine 94(1):e132. doi: 10.1097/MD.0000000000000132
  5. Ibrahim Zardawi and Peter Chong (2016) Metastatic Prostate Cancer to the Urethra Masquerading as Urothelial Carcinoma. Urology Case Reports 7:33. doi: 10.1016/j.eucr.2016.03.007

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