Go Back
This abstract was viewed 65 times

Original research article


Effect of magnesium sulfate on Doppler parameters of fetal umbilical and middle cerebral arteries in women with severe preeclampsia

Nazanin FarshchianNegin RezavandSaeed Mohammadi
Departments of Radiology and 1Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Date of Submission: 25-Sep-2012, Date of Acceptance: 07-Nov-2012, Date of Web Publication: 31-Dec-2012.
Corresponding Author:
Corresponding Author

Negin Rezavand

Department of Gynecology, Imam Reza Hospital, Kermanshah, Iran.
E-mail: nrezavand@kums.ac.ir

Corresponding Author:
Corresponding Author

Negin Rezavand

Department of Gynecology, Imam Reza Hospital, Kermanshah, Iran.
E-mail: nrezavand@kums.ac.ir

DOI: 10.4103/2156-7514.105269 Facebook Twitter Google Linkedin

ABSTRACT



Objective: To assess the effect of injecting magnesium sulfate on Doppler parameters of fetal umbilical and middle cerebral arteries (MCA) in women with severe preeclampsia.
Materials and Methods: A total of 21 patients with severe preeclampsia admitted to Imam Reza Hospital, Kermanshah (Iran), were evaluated. Before and after administration of magnesium sulfate, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery and umbilical artery blood flow. Paired t-test was used for statistical analysis.
Results: After injection of magnesium sulfate, the mean resistivity index (RI)-umbilical, and pulsatility index (PI)-cerebral showed a statistically significant reduction (P < 0.001). The cerebroumbilical C/U ratio increased after the intervention (P < 0.001). The PI-umbilical(P = 0.1) and pre- and post-RI-cerebral(P = 0.96) did not have statistically significant changes.
Conclusions: Infusion of magnesium sulfate significantly decreases the flow in the fetus RI-umbilical and PI-MCA, and it increases C/U ratio indices in color Doppler ultrasound.
Keywords: Doppler Ultrasound, Eclampsia, Magnesium Sulfate, Preeclampsia

Cited in 4 Documents

  1. Matthieu Lecuyer, Marina Rubio, Clément Chollat, Maryline Lecointre, Sylvie Jégou, Philippe Leroux, Carine Cleren, Isabelle Leroux-Nicollet, Loic Marpeau, Denis Vivien, Stéphane Marret and Bruno J. Gonzalez (2017) Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain. Pharmacol Res Perspect 5(4):e00315. doi: 10.1002/prp2.315
  2. Robert Galinsky, Joanne O. Davidson, Paul P. Drury, Guido Wassink, Christopher A. Lear, Lotte G. van den Heuij, Alistair J. Gunn and Laura Bennet (2016) Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep. J Physiol 594(5):1281. doi: 10.1113/JP270614
  3. A. Sotiriadis, E. Hernandez-Andrade, F. da Silva Costa, T. Ghi, P. Glanc, A. Khalil, W.P. Martins, A.O. Odibo, A.T. Papageorghiou, L.J. Salomon and B. Thilaganathan (2019) ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia. Ultrasound Obstet Gynecol 53(1):7. doi: 10.1002/uog.20105
  4. J. Suliburska, R. Kocyłowski, I. Komorowicz, M. Grzesiak, P. Bogdański and D. Barałkiewicz (2016) Concentrations of Mineral in Amniotic Fluid and Their Relations to Selected Maternal and Fetal Parameters. Biol Trace Elem Res 172(1):37. doi: 10.1007/s12011-015-0557-3

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.