Objective: To assess the effect of injecting magnesium sulfate on Doppler parameters of fetal umbilical and middle cerebral arteries (MCA) in women with severe preeclampsia. Materials and Methods: A total of 21 patients with severe preeclampsia admitted to Imam Reza Hospital, Kermanshah (Iran), were evaluated. Before and after administration of magnesium sulfate, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery and umbilical artery blood flow. Paired t-test was used for statistical analysis. Results: After injection of magnesium sulfate, the mean resistivity index (RI)-umbilical, and pulsatility index (PI)-cerebral showed a statistically significant reduction (P < 0.001). The cerebroumbilical C/U ratio increased after the intervention (P < 0.001). The PI-umbilical(P = 0.1) and pre- and post-RI-cerebral(P = 0.96) did not have statistically significant changes. Conclusions: Infusion of magnesium sulfate significantly decreases the flow in the fetus RI-umbilical and PI-MCA, and it increases C/U ratio indices in color Doppler ultrasound.
Matthieu Lecuyer, Marina Rubio, Clément Chollat, Maryline Lecointre, Sylvie Jégou, Philippe Leroux, Carine Cleren, Isabelle Leroux-Nicollet, Loic Marpeau, Denis Vivien, Stéphane Marret and Bruno J. Gonzalez (2017) Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain. Pharmacol Res Perspect5(4):e00315. doi: 10.1002/prp2.315
Robert Galinsky, Joanne O. Davidson, Paul P. Drury, Guido Wassink, Christopher A. Lear, Lotte G. van den Heuij, Alistair J. Gunn and Laura Bennet (2016) Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep. J Physiol594(5):1281. doi: 10.1113/JP270614
A. Sotiriadis, E. Hernandez-Andrade, F. da Silva Costa, T. Ghi, P. Glanc, A. Khalil, W.P. Martins, A.O. Odibo, A.T. Papageorghiou, L.J. Salomon and B. Thilaganathan (2019) ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia. Ultrasound Obstet Gynecol53(1):7. doi: 10.1002/uog.20105
J. Suliburska, R. Kocyłowski, I. Komorowicz, M. Grzesiak, P. Bogdański and D. Barałkiewicz (2016) Concentrations of Mineral in Amniotic Fluid and Their Relations to Selected Maternal and Fetal Parameters. Biol Trace Elem Res172(1):37. doi: 10.1007/s12011-015-0557-3
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.