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Original research article

Correlation of ultrasonographic parameters with serum creatinine in chronic kidney disease.

Jagdeesh K SiddappaSaurabh SinglaMohammed Al AmeenS C RakshithNaveen Kumar
Department of Radiodiagnosis, M. S. Ramaiah Medical College, Bangalore, India
Date of Submission: 29-Dec-2012, Date of Acceptance: 10-Jun-2013, Date of Web Publication: 30-Jun-2013.
Corresponding Author:
Corresponding Author

Saurabh Singla

B 101, M.S Palazzo, 491, Jakkur Main Road, Yelahanka Hobli, Bangalore ‑ 560 064, India.
E-mail: saurabh_6681@yahoo.com

Corresponding Author:
Corresponding Author

Saurabh Singla

B 101, M.S Palazzo, 491, Jakkur Main Road, Yelahanka Hobli, Bangalore ‑ 560 064, India.
E-mail: saurabh_6681@yahoo.com

DOI: 10.4103/2156-7514.114809 Facebook Twitter Google Linkedin


Objective: The purpose of our study is to correlate renal echogenicity with serum creatinine in order to determine the significance of renal echogenicity when it comes to identifying the progression of chronic kidney disease (CKD) and for the sonographic grading of CKD.
Materials and Methods: Sixty patients above 30 years of age who had been diagnosed with CKD according to the guidelines of the National Kidney Foundation were included in the study. Patients on kidney replacement therapy or with fatty liver findings on ultrasonography were excluded. Ultrasounds of kidneys were performed by two radiologists who were blind to the patients’ serum creatinine levels. Renal cortical echogenicity was compared with serum creatinine. Statistical analysis was performed using one-way ANOVA followed by Scheffe’s test. The relationship between serum creatinine and sonographic features was assessed by correlation coefficient analysis. A P value less than 0.05 was considered statistically significant.
Results: Mean serum creatinine was 2.80 mg/dl for Grade 1 (range: 0.9-9.2 mg/dl), 3.69 mg/dl for Grade 2 (range: 1.2-10.3 mg/dl), 3.86 mg/dl for Grade 3 (range: 1.1-6.5 mg/dl), and 7.90 mg/ dl for Grade 4 (range: 3.1-11.4 mg/dl). The grades being determined by cortical echogenicity on imaging A statistically significant, positive correlation was observed between serum creatinine and grading based on cortical echogenicity (P = 0.004).
Conclusion: Renal echogenicity and its grading correlates better with serum creatinine in CKD than other sonographic parameters such as longitudinal size, parenchymal thickness, and cortical thickness. Hence, renal echogenicity is a better parameter than serum creatinine for estimating renal function in CKD, and has the added advantage of irreversibility.
Keywords: Chronic Kidney Disease, Renal Echogenicity, Serum Creatinine

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  3. Chiara Mattei, Lena Pelander, Kerstin Hansson, Margareta Uhlhorn, Ulf Olsson, Jens Häggström, Ingrid Ljungvall and Charles J. Ley (2019) Renal ultrasonographic abnormalities are associated with low glomerular filtration rate calculated by scintigraphy in dogs. Vet Radiol Ultrasound :. doi: 10.1111/vru.12755
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  6. Iulia Grosu, Flaviu Bob, Ioan Sporea, Alina Popescu, Roxana Şirli and Adalbert Schiller (2018) Correlation of Point Shear Wave Velocity and Kidney Function in Chronic Kidney Disease. J Ultrasound Med 37(11):2613. doi: 10.1002/jum.14621
  7. Gioia Di Egidio, Stefano Masciovecchio, Pietro Saldutto, Giuseppe Paradiso Galatioto and Carlo Vicentini (2014) Imaging of Medullary Sponge Kidney: Notes for Urologists. Urologia Journal 81(4):196. doi: 10.5301/uro.5000074
  8. Cletus Uche Eze, Charles Ugwoke Eze and Adekunle A. O. Adeyomoye (2018) Renal Echogenicity as a Predictor of Human Immunodeficiency Virus–Associated Nephropathy: A Cross-Sectional Study at a Tertiary Hospital in Lagos, Southwest Nigeria. Journal of Diagnostic Medical Sonography 34(4):261. doi: 10.1177/8756479318774767

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