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Radiologic-Pathologic correlation


Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature.

Danielle M RichmanScott C BreslerMichael H RosenthalStephanie Anne Holler Howard
Department of Imaging,Dana-Farber Cancer Institute, Departments of Radiology, and Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Date of Submission: 23-Jan-2015, Date of Acceptance: 08-Feb-2015, Date of Web Publication: 27-Feb-2015.
Corresponding Author:
Corresponding Author

Danielle M Richman

Department of Radiology, Brigham and Women’s Hospital, Boston ‑ 02115, Massachusetts, USA.
E-mail: DMRichman@partners.org

Corresponding Author:
Corresponding Author

Danielle M Richman

Department of Radiology, Brigham and Women’s Hospital, Boston ‑ 02115, Massachusetts, USA.
E-mail: DMRichman@partners.org

DOI: 10.4103/2156-7514.152343 Facebook Twitter Google Linkedin

ABSTRACT


Malignant tenosynovial giant cell tumor (TGCT) is a rare clinical entity that can arise as a recurrent lesion or can co‑exist with a benign TGCT lesion. Malignant TGCT most commonly arises in the lower extremity and tends to be clinically aggressive, with most patients developing recurrent lesions or dying. Much of the literature describes the histopathologic features and classifies this broad group of tumors, with little description of the imaging characteristics of this disease. We present the multimodality appearance of a case of malignant diffuse‑type TGCT that recurred 2 months after resection with subsequent rapid clinical progression.
Keywords: Diffuse‑type tenosynovial giant cell tumor, malignant tenosynovial giant cell tumor, pulmonary metastasis, tenosynovial giant cell tumor

Cited in 5 Documents

  1. A. Shah, R. Botchu, A. M. Davies and S. L. James (2017) Imaging of Soft Tissue Tumors. (Chapter 14):311. doi: 10.1007/978-3-319-46679-8_14
  2. Casper Falster, Simon Stockmann Poulsen and Uffe Joergensen (2017) A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. BMJ Case Reports :bcr-2017-219549. doi: 10.1136/bcr-2017-219549
  3. Alyaa Al-Ibraheemi, William Albert Ahrens, Karen Fritchie, Jie Dong, Andre M. Oliveira, Bonnie Balzer and Andrew L. Folpe (2019) Malignant Tenosynovial Giant Cell Tumor: The True “Synovial Sarcoma?” A Clinicopathologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases, Supporting Origin from Synoviocytes. Mod Pathol 32(2):242. doi: 10.1038/s41379-018-0129-0
  4. Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick and Andrew J. Wagner (2018) Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy. BMC Cancer 18(1):. doi: 10.1186/s12885-018-5188-6
  5. Soo Jung Kim, Yong-Koo Kang, Chang Young Yoo and Jee Young Kim (2016) Tenosynovial Giant Cell Tumor of the Pes Anserine Bursa with Bone Marrow Extension into the Tibia: A Case Report. J Korean Soc Radiol 75(4):322. doi: 10.3348/jksr.2016.75.4.322

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