Metaplastic breast cancer is a rare malignancy in the breast. Neurofibromatosis Type 1 is an autosomal dominant multisystem disorder associated with multiple neoplasms such as optic gliomas and peripheral nerve sheath tumors. The association of breast cancer with neurofibromatosis is very rare. We present a case of a metaplastic breast cancer in a patient with Type 1 neurofibromatosis. The patient presented with a palpable mass in her left breast with suspicious findings on mammogram and ultrasound. Ultrasound-guided percutaneous biopsy showed metaplastic breast carcinoma with metastasis to an axillary lymph node. This is the third case report in the English literature to show metaplastic breast carcinoma in a patient with Type 1 neurofibromatosis. In this report we review recent literature and discuss the association between these two entities.
Keywords: Breast Imaging, Metaplastic Breast Carcinoma, Neurofibromatosis
Cited in 2 Documents
Amy E McCart Reed and Sunil R Lakhani (2019) A Molecular and Morphological Deep-Dive Into Metaplastic Breast Cancers. Cancer Inform18:117693511985015. doi: 10.1177/1176935119850155
Amy Ellen McCart Reed, Emarene Kalaw, Katia Nones, Mark Bettington, Malcolm Lim, James Bennett, Kate Johnstone, Jamie Rose Kutasovic, Jodi Marie Saunus, Stephen Kazakoff, Qinying Xu, Scott Wood, Oliver Holmes, Conrad Leonard, Lynne Estelle Reid, Debra Black, Colleen Niland, Kaltin Ferguson, Irma Gresshoff, Ashwini Raghavendra, Kate Harvey, Caroline Cooper, Cheng Liu, Lauren Kalinowski, Andrew Scott Reid, Morgan Davidson, John V Pearson, Nirmala Pathmanathan, Gary Tse, David Papadimos, Rajadurai Pathmanathan, Gavin Harris, Rin Yamaguchi, Puay Hoon Tan, Stephen B Fox, Sandra A O'Toole, Peter Thomas Simpson, Nicola Waddell and Sunil R Lakhani (2019) Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications. J. Pathol.247(2):214. doi: 10.1002/path.5184
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.