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Case report


Metaplastic breast cancer in a patient with neurofibromatosis.

Umar Shafique ChaudhryLimin YangRyan W AskelandLaurie L Fajardo
Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, Department of Pathology, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota, USA
Date of Submission: 16-Jan-2015, Date of Acceptance: 14-Mar-2015, Date of Web Publication: 27-Mar-2015.
Corresponding Author:
Corresponding Author

Limin Yang

Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
E-mail: limin‑yang@uiowa.edu

Corresponding Author:
Corresponding Author

Limin Yang

Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
E-mail: limin‑yang@uiowa.edu

DOI: 10.4103/2156-7514.154102 Facebook Twitter Google Linkedin

ABSTRACT


Metaplastic breast cancer is a rare malignancy in the breast. Neurofibromatosis Type 1 is an autosomal dominant multisystem disorder associated with multiple neoplasms such as optic gliomas and peripheral nerve sheath tumors. The association of breast cancer with neurofibromatosis is very rare. We present a case of a metaplastic breast cancer in a patient with Type 1 neurofibromatosis. The patient presented with a palpable mass in her left breast with suspicious findings on mammogram and ultrasound. Ultrasound-guided percutaneous biopsy showed metaplastic breast carcinoma with metastasis to an axillary lymph node. This is the third case report in the English literature to show metaplastic breast carcinoma in a patient with Type 1 neurofibromatosis. In this report we review recent literature and discuss the association between these two entities.
Keywords: Breast Imaging, Metaplastic Breast Carcinoma, Neurofibromatosis

Cited in 2 Documents

  1. Amy E McCart Reed and Sunil R Lakhani (2019) A Molecular and Morphological Deep-Dive Into Metaplastic Breast Cancers. Cancer Inform 18:117693511985015. doi: 10.1177/1176935119850155
  2. Amy Ellen McCart Reed, Emarene Kalaw, Katia Nones, Mark Bettington, Malcolm Lim, James Bennett, Kate Johnstone, Jamie Rose Kutasovic, Jodi Marie Saunus, Stephen Kazakoff, Qinying Xu, Scott Wood, Oliver Holmes, Conrad Leonard, Lynne Estelle Reid, Debra Black, Colleen Niland, Kaltin Ferguson, Irma Gresshoff, Ashwini Raghavendra, Kate Harvey, Caroline Cooper, Cheng Liu, Lauren Kalinowski, Andrew Scott Reid, Morgan Davidson, John V Pearson, Nirmala Pathmanathan, Gary Tse, David Papadimos, Rajadurai Pathmanathan, Gavin Harris, Rin Yamaguchi, Puay Hoon Tan, Stephen B Fox, Sandra A O'Toole, Peter Thomas Simpson, Nicola Waddell and Sunil R Lakhani (2019) Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications. J. Pathol. 247(2):214. doi: 10.1002/path.5184

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