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Radiologic-Pathologic correlation


Pulmonary Tumor Thrombotic Microangiopathy: Clinical, Radiologic, and Histologic Correlation.

Rohit GodboleAbhijeet GhatolJamie BetancourtJohn SacoolidgeNader Kamangar
Department of Medicine and Department of Pathology, Olive View – UCLA Medical Center, Division of Pulmonary and Critical Care Medicine, Olive View – UCLA Medical Center, Sylmar, Division of Pulmonary and Critical Care Medicine, West Los Angeles Veterans Affairs Medical Center, Los Angeles, California, USA
Date of Submission: 14-Jun-2015, Date of Acceptance: 28-Jul-2015, Date of Web Publication: 31-Jul-2015.
Corresponding Author:
Corresponding Author

Nader Kamangar

Division of Pulmonary and Critical Care Medicine, UCLA – Olive View Medical Center, David Geffen School of Medicine at UCLA, 14445 Olive View Drive, Room 2B‑182, Sylmar, California 91342, USA.
E-mail: kamangar@ucla.edu

Corresponding Author:
Corresponding Author

Nader Kamangar

Division of Pulmonary and Critical Care Medicine, UCLA – Olive View Medical Center, David Geffen School of Medicine at UCLA, 14445 Olive View Drive, Room 2B‑182, Sylmar, California 91342, USA.
E-mail: kamangar@ucla.edu

DOI: 10.4103/2156-7514.161978 Facebook Twitter Google Linkedin

ABSTRACT


Pulmonary tumor thrombotic microangiopathy (PTTM) is a clinicopathologic disease entity in which the tumor cells embolize to the pulmonary vasculature leading to a series of maladaptive reactions including the activation of coagulation and fibrocellular intimal thickening. The resultant stenosis of blood vessels leads to pulmonary hypertension and eventual death from cor pulmonale. In this report, we present a case of PTTM presenting as the initial manifestation of metastatic gastric carcinoma in a young man. Although unusual in its occurrence as the initial manifestation of gastric carcinoma, the case is illustrative in its clinical, radiological and histological presentation.
Keywords: Cancer, Embolism, Pulmonary Hypertension

Cited in 8 Documents

  1. Laura C. Price, Athol U. Wells and Stephen J. Wort (2016) Pulmonary tumour thrombotic microangiopathy. Current Opinion in Pulmonary Medicine 22(5):421. doi: 10.1097/MCP.0000000000000297
  2. Rohit Godbole, Rajan Saggar, Alexander Zider, Jamie Betancourt, William D. Wallace, Robert D. Suh and Nader Kamangar (2017) Insights on pulmonary tumor thrombotic microangiopathy: a seven-patient case series. Pulm Circ 7(4):813. doi: 10.1177/2045893217728072
  3. Melanie C. Bois, Michael D. Eckhardt, Vincent M. Cracolici, Matthew J. Loe, Joseph J. Ocel, William D. Edwards, Robert D. McBane, Thomas C. Bower and Joseph J. Maleszewski (2018) Neoplastic embolization to systemic and pulmonary arteries. Journal of Vascular Surgery 68(1):204. doi: 10.1016/j.jvs.2017.09.045
  4. Fatima A. Ballout, Ahmad S. Manshad and Tochukwu M. Okwuosa (2017) Pulmonary Hypertension and Cancer: Etiology, Diagnosis, and Management. Curr Treat Options Cardio Med 19(6):. doi: 10.1007/s11936-017-0543-5
  5. Josh Curtis Hutchinson, James W. Fulcher, Jeff Hanna and Michael E. Ward (2017) Pulmonary Tumor Thrombotic Microangiopathy. The American Journal of Forensic Medicine and Pathology :1. doi: 10.1097/PAF.0000000000000369
  6. Daisuke Katayama, Keiko Kuriyama, Tatsuya Kinoshita, Keisuke Nagai, Hidenari Hongyo, Kentaro Kishimoto, Atsuo Inoue, Manabu Takamura and Soomi Choi (2016) Pulmonary tumor thrombotic microangiopathy caused by prostate carcinoma. Acta Radiologica Open 5(8):205846011666230. doi: 10.1177/2058460116662300
  7. M. Merad, A. Alibay, S. Ammari, S. Antoun, A. Bouguerba, S. Ayed and F. Vincent (2017) Microangiopathie thrombotique tumorale pulmonaire. Revue des Maladies Respiratoires 34(10):1045. doi: 10.1016/j.rmr.2017.02.008
  8. Laura C. Price, Michael J. Seckl, Peter Dorfmüller and S. John Wort (2019) Tumoral pulmonary hypertension. Eur Respir Rev 28(151):180065. doi: 10.1183/16000617.0065-2018

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