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Case report


Human Herpes Virus-8-Associated Multicentric Castleman's Disease in a Human Immunodeficiency Virus-Positive Patient with a Previous History of Kaposi's Sarcoma.

Guan HuangGavin Low
Department of Radiology and Diagnostic Imaging, University of Alberta Hospital, Edmonton, Alberta, Canada
Date of Submission: 21-Sep-2015, Date of Acceptance: 21-Oct-2015, Date of Web Publication: 30-Oct-2015.
Corresponding Author:
Corresponding Author

Guan Huang

Department of Radiology and Diagnostic Imaging, University of Alberta Hospital, 2A2.41 WMC, 8440‑112 Street, Edmonton, Alberta T6G 2B7, Canada.
E-mail: guanhuang@gmail.com

Corresponding Author:
Corresponding Author

Guan Huang

Department of Radiology and Diagnostic Imaging, University of Alberta Hospital, 2A2.41 WMC, 8440‑112 Street, Edmonton, Alberta T6G 2B7, Canada.
E-mail: guanhuang@gmail.com

DOI: 10.4103/2156-7514.168713 Facebook Twitter Google Linkedin

ABSTRACT


Human herpes virus-8 (HHV-8)-associated Castleman's disease (CD) is a rare non-cancerous B-cell lymphoproliferative disorder in human immunodeficiency virus (HIV)-positive patients. We report a case of HHV-8-associated CD in an HIV-positive patient with a previous history of Kaposi's sarcoma (KS). The patient presented with progressive splenomegaly and diffuse lymphadenopathy, which can be seen in multicentric CD, KS, and HIV-associated lymphoma. There are no reliable clinical or imaging features to differentiate these diseases. Lymph node biopsy confirmed HHV-8-associated CD and excluded KS and lymphoma. Due to differences in treatment options and prognosis between the three etiologies, it is important for radiologists to include HHV-8-associated CD in the differential diagnosis when encountering HIV-positive patients that present with diffuse lymphadenopathy.
Keywords: Human Immunodeficiency Virus, Kaposi's Sarcoma, Multicentric Castleman's Disease

Cited in 3 Documents

  1. Arthur Zimmermann (2016) Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. (Chapter 94-1):1. doi: 10.1007/978-3-319-26587-2_94-1
  2. Uyen Mui, Christopher Haley and Stephen Tyring (2017) Viral Oncology: Molecular Biology and Pathogenesis. JCM 6(12):111. doi: 10.3390/jcm6120111
  3. Arthur Zimmermann (2017) Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. (Chapter 94):1671. doi: 10.1007/978-3-319-26956-6_94

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