Rare Intensely Fluorine-18-fluorodeoxyglucose Avid Large Retropharyngeal Goiter in a Patient with Invasive Breast Carcinoma
Bina Kviatkovsky1, Elliot Landau2, Muhammad Siddique3, Arnold Brenner1
1Touro College of Osteopathic Medicine, New York, NY 10027, 2Department of Radiology, Staten Island University Hospital, 3Department of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY 10305, USA
Date of Submission: 26-Jan-2016, Date of Acceptance: 03-Mar-2016, Date of Web Publication: 30-Mar-2016.
Diffuse increased fluorine-18-fluorodeoxyglucose (18F-FDG) avidity on positron emission tomography (PET) scans has been demonstrated in patients with chronic thyroiditis, likely secondary to increased inflammatory cell glucose uptake. A complex association has been demonstrated between breast cancer and thyroid disease, although the mechanism remains elusive. Development of chronic thyroiditis and/or goiter in breast cancer patients has been suggested to convey a more favorable prognosis. Goiter extension is almost exclusively into retrosternal space, with only a handful of cases reported with superior extension into retropharyngeal space. We present a rare case of a diffusely enlarged goiter extending superior and posterior into the retropharyngeal space with an associated intense 18F-FDG avidity standardized uptake value maximum (SUVmax) of 16.1 in a patient with invasive ductal breast cancer. To our knowledge, this represents the first published case of diffusely 18F-FDG avid goiter with retropharyngeal extension.
Keywords: Breast cancer, fluorine-18-fluorodeoxyglucose, goiter, positron emission tomography, retropharyngeal
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