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Original research article


Elastography in Distinguishing Benign from Malignant Thyroid Nodules.

Bulent ColakogluDuzgun YildirimDeniz AlisGokhan UcarCesur SamanciFethi Emre UstabasiogluAlev BakirOnur Levent Ulusoy
Date of Submission: 17-Sep-2016, Date of Acceptance: 29-Nov-2016, Date of Web Publication: 29-Dec-2016.
Corresponding Author:
Corresponding Author

Deniz Alis

Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
E-mail: drdenizalis@gmail.com

Corresponding Author:
Corresponding Author

Deniz Alis

Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
E-mail: drdenizalis@gmail.com

DOI: 10.4103/2156-7514.197074 Facebook Twitter Google Linkedin

ABSTRACT



Aim: The aim of this study is to test the diagnostic success of strain elastography in distinguishing benign from malignant thyroid nodules.
Materials and Methods: The size, echogenicity, and halo integrity of 293 thyroid nodules and the presence of microcalcification in these nodules were evaluated on gray-scale examination. Doppler characteristics and elastography patterns were also evaluated and recorded. Nodules were classified in four categories (patterns 1–4) based on elastographic examination.
Results: According to the cytopathological findings, 222 nodules were benign, and 71 nodules were malignant. The risk of a nodule to be malignant was 3.8 times increased by hypoechogenicity, 7.7 times increased by the presence of microcalcification, and 11.5 times increased by the absence of halo. On Doppler patterns, the presence of central vascularity increased the malignancy risk of a nodule by 5.8 times. According to the receiver operating characteristic analysis, patterns 3 and 4 were malignant, and patterns 1 and 2 were benign. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of elastography were 100%, 80.2%, 61.7%, 100%, and 85%, respectively.
Conclusion: Strain elastography can be used as a noninvasive method in distinguishing benign from malignant thyroid nodules and in identifying the patients who would undergo surgery.
Keywords: Benign, Elastography, Malignant, Thyroid Nodule

Cited in 1 Document

  1. Bao-liang Guo, Fu-sheng Ouyang, Li-zhu Ouyang, Zi-wei Liu, Shao-jia Lin, Wei Meng, Xi-yi Huang, Hai-xiong Chen, Shao-ming Yang and Qiu-gen Hu (2019) Development and validation of an ultrasound-based nomogram to improve the diagnostic accuracy for malignant thyroid nodules. Eur Radiol 29(3):1518. doi: 10.1007/s00330-018-5715-5

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