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Original research article


Fluorine-18-fluorodihydroxyphenylalanine Positron-emission Tomography Scans of Neuroendocrine Tumors (Carcinoids and Pheochromocytomas).

Italo ZanziYana StudentsovaDavid BjelkeRichard WarnerBarry BabchyckThomas Chaly
1Feinstein Institute for Medical Research, Northwell HealthDepartment of Radiology, North Shore University Hospital, Northwell Health, Manhasset, NY,Center for Carcinoid/Neuroendocrine Tumors, Mount Sinai School of Medicine, Carcinoid Cancer Foundation, New York, USA
Date of Submission: 29-Dec-2016, Date of Acceptance: 17-Mar-2017, Date of Web Publication: 22-May-2017.
Corresponding Author:
Corresponding Author

Italo Zanzi

27 Aerie Court, Manhasset, NY 11030, USA.
E-mail: izanzi@northwell.edu

Corresponding Author:
Corresponding Author

Italo Zanzi

27 Aerie Court, Manhasset, NY 11030, USA.
E-mail: izanzi@northwell.edu

DOI: 10.4103/jcis.JCIS_107_16 Facebook Twitter Google Linkedin

ABSTRACT



Objectives: Conventional methods of imaging neuroendocrine tumors with computed tomography, magnetic resonance imaging, indium-111-octreotide, or radiolabeled metaiodobenzilguanidine scintigraphy have limitations. This pilot study tried to improve the localization of these tumors with fluorine-18-fluorodihydroxyphenylalanine (F-DOPA) positron-emission tomography (PET) scanning.
Materials and Methods: We studied 22 patients, the majority of whom were referred with clinical diagnosis or suspicion of carcinoid (n = 11), neuroendocrine tumors (n = 7) or pheochromocytoma/paraganglioma (PGL) (n = 4). The comparison was made with the prior conventional imaging.
Results: The F-DOPA findings were compared with the results of subsequent surgery (2), endoscopy (1), or a long-term follow-up (mean duration, 49 months) for 17 patients. Two patients were lost to follow-up. Foci of F-DOPA deposition were detected in eight patients (final diagnosis of carcinoid in six, of neuroendocrine tumors in one, and of PGL in another). Comparison with the final diagnoses revealed concordance in 16 of the 22 patients. F-DOPA results appeared superior to those obtained with conventional imaging. Despite the small number and diagnostic heterogeneity, in a substantial fraction of patients F-DOPA PET added information relevant to clinical management.
Conclusion: F-DOPA scanning added prognostic value, particularly when multiple abnormal foci versus a negative examination were considered.
Keywords: Carcinoid, Fluorodihydroxyphenylalanine Positron-emission Tomography, Neuroendocrine Tumor, Pheochromocytoma/paraganglioma

Cited in 1 Document

  1. Nadine Mallak, Thomas A. Hope and Alexander R. Guimaraes (2018) PET/MR Imaging of the Pancreas. Magnetic Resonance Imaging Clinics of North America 26(3):345. doi: 10.1016/j.mric.2018.03.003

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