Laboratory Tests, Liver Vessels Color Doppler Sonography, and FibroScan Findings in Patients with Nonalcoholic Fatty Liver Disease: An Observation Study.
Ahmad Alizadeh1, Fariborz Mansour-Ghanaei2, Ava Roozdar1, Farahnaz Joukar3, Masood Sepehrimanesh4, Seyedeh Amineh Hojati3, Alireza Mansour-Ghanaei5
1Department of Radiology, Poursina Hospital, Guilan University of Medical Sciences, 2Gastrointestinal and Liver Diseases Research Center, Razi Hospital, Guilan University of Medical Sciences, 3Caspian Digestive Diseases Research Center, Guilan University of Medical Science, 4Gastrointestinal Cancer Screening and Prevention Research Center, Guilan niversity of Medical Sciences, Rasht, 5Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Date of Submission: 16-Dec-2017, Date of Acceptance: 12-Feb-2018, Date of Web Publication: 03-Apr-2018.
Objective:Determination of the amount of parenchymal damage in nonalcoholic fatty liver disease (NAFLD) is crucial to choose the best treatment and management. Aim: Here, the associations between laboratory data and severity of steatosis and fibrosis plus hepatic vessel Doppler indices in NAFLD patients were investigated. Patients and Methods: Fifty patients (20 males and 30 females) with NAFLD criteria were enrolled. Fatty liver was graded by sonography (SGFL) and FibroScan (FGFL). In addition, liver fibrosis was graded through FGLF. Damages to the portal, hepatic, and splenic veins were evaluated by color Doppler/dopplex. Serum liver enzymes and C-reactive protein (CRP) were also measured. Results: Significant association existed between SGFL and FGFL (P = 0.006). Portal vein pulsatility index (PI) and phasicity plus the triphasic and monophasic pattern of hepatic veins significantly associated with fatty liver grade evaluated by sonography. Splenic vein Peak systolic velocity and PI showed significant association with FGFL. Eventually, elevated liver enzymes and CRP significantly correlated with FGLF. Conclusion: We found that the severity of fatty liver is correlated with hepatic and portal veins damages; however, the degree of parenchymal fibrosis was independent to these indices and can be directly evaluated by FGFL. In addition, elevated liver enzymes and CRP correlated with the degree of fibrosis
Keywords: Color Doppler, fibroScan, nonalcoholic fatty liver disease, sonography
Cited in 4 Documents
Jing Meng, Hongqin Xu, Xu Liu, Ruihong Wu and Junqi Niu (2018) Increased red cell width distribution to lymphocyte ratio is a predictor of histologic severity in primary biliary cholangitis. Medicine97(48):e13431. doi: 10.1097/MD.0000000000013431
Li-Li Wu, Jing Zhou, Qing-Xian Cai, Ya-Xin Huang, Dong-Ying Xie, Zhi-Liang Gao and Hong Deng (2018) Liver Fibrosis is Associated with NAFLD Activity Score in Chronic Hepatitis B Patients with Liver Steatosis. Hepat MonIn Press(In Press):. doi: 10.5812/hepatmon.84182
Kokab Namakin, Mahya Hosseini, Mahmoud Zardast and Mahyar Mohammadifard (2018) Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and its Clinical Characteristics in Overweight and Obese Children in the South East of Iran, 2017. Hepat MonIn Press(In Press):. doi: 10.5812/hepatmon.83525
Ahmad Hormati, Maryam Jameshorani, Seyed Saeed Sarkeshikian , Mansureh Molaei, Mahdi Jahangiri and Mohammad Reza Ghadir (2019) Effects of Atorvastatin Alongside Conventional Medical Treatment on Liver Fibrosis and Dysfunction in Patients with Chronic Hepatitis B: A Double-Blinded Clinical Trial. Hepat MonIn Press(In Press):. doi: 10.5812/hepatmon.84656
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.