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Original research article


Assessment of the Agreement between Cerebral Hemodynamic Indices Quantified Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced Perfusion Magnetic Resonance Imagings

Seyed Salman Zakariaee1Mohammad Ali Oghabian1,2Kavous Firouznia3Guive Sharifi4Farshid Arbabi5Farhad Samiei6
1Departments of Medical Physics and Biomedical Engineering, 2Radiology and, 3Radiotherapy, Faculty of Medicine, Tehran University of Medical Sciences, 4Research Center For Molecular and Cellular Imaging, Neuroimaging and Analysis Group, Tehran University of Medical Sciences, 5Department of Neurosurgery, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 6Department of Radiotherapy, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Date of Submission: 18-Oct-2017, Date of Acceptance: 10-Dec-2017, Date of Web Publication: 22-Jan-2018.
Corresponding Author:
Corresponding Author

Mohammad Ali Oghabian

E-mail: oghabian@sina.tums.ac.ir

Corresponding Author:
Corresponding Author

Mohammad Ali Oghabian

E-mail: oghabian@sina.tums.ac.ir

DOI: 10.4103/jcis.JCIS_74_17 Facebook Twitter Google Linkedin

ABSTRACT



Background: Brain tumor is one of the most common tumors. A successful treatment might be achieved with an early identification. Pathological investigation as the gold standard method for tumor identification has some limitations. Noninvasive assessment of tumor specifications may be possible using perfusion-weighted magnetic resonance imaging (MRI). Cerebral blood volume (CBV) and cerebral blood flow (CBF) could be calculated based on dynamic contrast-enhanced MRI (DCE-MRI) in addition to dynamic susceptibility contrast MRI (DSC-MRI) modality. Each category of the cerebral hemodynamic and permeability indices revealed the specific tumor characteristics and their collection could help for better identification of the tumor. Some mathematical methods were developed to determine both cerebral hemodynamic and permeability indices based on a single-dose DCE perfusion MRI. There are only a few studies available on the comparison of DSC- and DCE-derived cerebral hemodynamic indices such as CBF and CBV.
Aim: The objective of the study was to validate first-pass perfusion parameters derived from T1-based DCE method in comparison to the routine T2*-based DSC protocol.
Materials and Methods: Twenty-nine patients with brain tumor underwent DCE- and DSC-MRIs to evaluate the agreement between DSC- and DCE-derived cerebral hemodynamic parameters. Agreement between DSC- and DCE-derived cerebral hemodynamic indices was determined using the statistical method described by Bland and Altman. The reliability between DSC- and DCE-derived cerebral hemodynamic indices was measured using the intraclass correlation analysis.
Results: The achieved magnitudes for DCE-derived CBV (gray matter [GM]: 5.01 ± 1.40 mL/100 g vs. white matter [WM]: 1.84 ± 0.74 mL/100 g) and DCE-derived CBF (GM: 60.53 ± 12.70 mL/100 g/min vs. WM: 32.00 ± 6.00 mL/100 g/min) were in good agreement with other studies. The intraclass correlation coefficients showed that the cerebral hemodynamic indices could accurately be estimated based on the DCE-MRI using a single-compartment model (>0.87), and DCE-derived cerebral hemodynamic indices are significantly similar to the magnitudesachieved based on the DSC-MRI (P < 0.001). Furthermore,an acceptable agreement was observed between DSC- and DCE-derived cerebral hemodynamic indices.
Conclusion: Based on the measurement of the cerebral hemodynamic and blood–brain barrier permeability using DCE-MRI, a more comprehensive collection of the physiological parameters cloud be achieved for tumor evaluations.
Keywords: Bland and Altman analysis, brain tumor, cerebral hemodynamic indices, dynamic contrast-enhanced-magnetic resonance imaging, dynamic susceptibility contrast-magnetic resonance imaging, intraclass correlation coefficient

Cited in 2 Documents

  1. Muhammad Asaduddin, Won-Joon Do, Eung Yeop Kim and Sung-Hong Park (2019) Mapping cerebral perfusion from time-resolved contrast-enhanced MR angiographic data. Magnetic Resonance Imaging 61:143. doi: 10.1016/j.mri.2019.05.040
  2. L. McKetton, L. Venkatraghavan, C. Rosen, D.M. Mandell, K. Sam, O. Sobczyk, J. Poublanc, E. Gray, A. Crawley, J. Duffin, J.A. Fisher and D.J. Mikulis (2019) Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease. AJNR Am J Neuroradiol 40(1):45. doi: 10.3174/ajnr.A5912

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