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Original research article


Role of Acoustic Radiation Force Impulse Elastography in the Characterization of Focal Solid Hepatic Lesions.

Harshavardhan Nagolu1Sudhakar Kattoju1Chidambaranathan Natesan1Meera Krishnakumar1Sunil Kumar2
1Departments of Radiology and Imaging Sciences and, 2Pathology, Apollo Hospitals, Chennai, Tamil Nadu, India
Date of Submission: 21-Aug-2017, Date of Acceptance: 28-Nov-2017, Date of Web Publication: 21-Feb-2018.
Corresponding Author:
Corresponding Author

Harshavardhan Nagolu

Old No: 19-9-6 A/5, New No: 19-41-S5-1192, Jayanagar, Backside Hotel Bliss, Tirupati - 517 501, Andhra Pradesh, India.
E-mail: drharsha003@gmail.com

Corresponding Author:
Corresponding Author

Harshavardhan Nagolu

Old No: 19-9-6 A/5, New No: 19-41-S5-1192, Jayanagar, Backside Hotel Bliss, Tirupati - 517 501, Andhra Pradesh, India.
E-mail: drharsha003@gmail.com

DOI: 10.4103/jcis.JCIS_64_17 Facebook Twitter Google Linkedin

ABSTRACT



Objective: The purpose of the study is to investigate the usefulness of acoustic radiation force impulse (ARFI) elastography in the characterization of focal solid liver lesions as benign, malignant, or metastatic using ARFI two-dimensional (2D) imaging and ARFI quantification (shear wave velocities [SWVs]).
Materials and Methods: Sixty lesions were included in this study. The lesions were classified into three groups: Group I included benign lesions (n = 25), Group II included malignant lesions (n = 27), and Group III included metastatic lesions (n = 8). ARFI elastography was performed in all these patients using a Siemens ACUSON S 2000TM ultrasound machine. Stiffness and size of the lesions were assessed on ARFI 2D images in correlation with B-mode ultrasound images. SWVs were obtained in these lesions for the quantification of stiffness.
Results: In ARFI 2D images, malignant lesions were predominantly stiffer and larger, while benign lesions were softer and similar in size (P < 0.05). The mean SWVs in benign, malignant, and metastatic lesions were 1.30 ± 0.35 m/s, 2.93 ± 0.75 m/s, and 2.77 ± 0.90 m/s, respectively. The area under receiver operating characteristic curve of SWV for differentiating benign from malignant lesions was 0.877, suggesting fair accuracy (95% confidence interval: 0.777–0.976); with a cutoff value of 2 m/s, showing sensitivity: 92%; specificity: 96%; positive predictive value: 96%; negative predictive value: 93% (P < 0.05). Statistically significant difference exists in SWV of benign and malignant or metastatic lesions.
Conclusion: ARFI elastography with 2D imaging and quantification might be useful in the characterization of benign and malignant liver lesions.
Keywords: Acoustic radiation force impulse, elasticity imaging, elastography, liver tumors, shear wave velocities

Cited in 1 Document

  1. V. E. Zagaynov, N. M. Kiselev, V. A. Belskiy, P. I. Rykhtik and N. V. Bobrov (2019) "Big trifles" of advanced liver resections for alveococcosis. Ann. hir. gepatol. 23(4):33. doi: 10.16931/1995-5464.2018433-44

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